Abstract
A series of clinical problems caused by mucosal immune damage in children′s immune diseases need to be paid more attention. The pathogenesis is complex and the clinical manifestations are various, which may lead to misdiagnosis and missed the right treatment. The clinical phenotypes of allergic, autoimmune and inflammatory diseases, and primary immunodeficiency diseases often overlap.The immunological characteristics of mucosal immune system, the characteristics of several related clinical immune diseases, the characteristics of serum immunoglobulin(Ig) E and IgG, the difference roles between specific IgE and IgG in allergic and autoimmune diseases, the role of mucosal immune system and probiotics, mucosal immune system and vaccine, the role of mucosal immune system in the diagnosis and treatment in the related immune diseases were reviewed in this article. The treatment of IgG4-related diseases and other aspects are elaborated to show the research progress of blood IgE and mucosal immune damage in immune diseases. Key words: Blood immunoglobulin E; Immune disease; Mucosal immunity
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