Abstract
Background: To assess, in non vaccinated healthy adults, the response to the standard protocol SP (0, 1, 6 months), and the response to two protocols using additional boosters in those who remain nonresponders. Methods & Materials: 192 employees of the Psychiatric Hospital of the Cross with a mean age of 44.3 (44.3 ± 12.35), non vaccinated and not having other illness (hepatic failure, chronic renal failure, HIV infection, cancer and active hepatitis C),are vaccinated with Engerix B (Engerix® B 20 μg/1 ml) by the SP. The non responders to this protocol (anti-Hbs antibodies < 10UI/l) are divided into two groups. The first group receives a single booster (R1) 4 months after the SP, and those who remained nonresponders receive a double booster (R1b) 2 years after the SP. The second group (P2) receives a unique double booster (R2), 2 years after the SP. Results: The rate of response after the vaccination by the SP is 75.5%(145/192). 28 nonresponders (P1) receive a booster R1 after 4 months, their rate of response is 32.14%(9/28). The 19 nonresponders to R1 receive a double booster (R1b) after 2 years. Their rate of response is 36.84%(7/19). The rate of response among the group P1 is 57.14%(16/28). 19 nonresponders (P2) receive a unique double booster after 2 years. Their rate of response is 63.16%(12/19). 9.9%(19/192) of individuals don’t respond to any of the boosters. The rate of response decreases with the age. This decrease is 5% every year and 41% every 10 years. For the same age, men are 2 fold more responders then women. After receiving all boosters, there is no difference between genders. Conclusion: A unique double booster done 2 years after the SP gives a better response then a single booster done after 4 months, and a similar response to a single booster done after 4 months followed by a double booster done after 2 years. The female gender and the age are 2 factors that decrease the response to the vaccination.
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