Abstract
The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7 mJ/cm2 was sufficient to achieve a more than 3-log inactivation without any sign of viral replication. Moreover, a complete inactivation at all viral concentrations was observed with 16.9 mJ/cm2. These results could explain the epidemiological trends of COVID-19 and are important for the development of novel sterilizing methods to contain SARS-CoV-2 infection.
Highlights
The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 multiplicity of infection (MOI))
We report the effect of monochromatic UV-C (254 nm) on SARS-CoV-2, showing that virus inactivation can be achieved
Hospital rooms), the second one corresponds to the average concentration found in the sputum of COVID-19 infected patients, and the third one is a very large concentration, corresponding to that observed in terminally diseased COVID-19 p atients[29]
Summary
The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). A better understanding of the effects of UV-C on SARS-CoV-2, which take into account all the key factors involved in the experimental setting (including culture medium, SARS-CoV-2 concentration, UV-C irradiance, time of exposure, and UV-C absorbance) will allow to replicate the results in other laboratory with different devices.
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