Abstract
Attempts to isolate thymine, thymidine or TMP deficient mutants from Neisseria meningitidis were altogether negative. This led to the examination of the growth response and the uptake of these compounds when exogenously added. The growth rate was slightly increased upon their addition to cultures of meningococci adapted to growth on basal media. At the same time, radioactivity was taken up from labelled thymine to an extent of 5.6 per cent of the material added, from thymidine to an extent of 0.6 per cent, and from TMP to an extent of 0.05 per cent. The addition of purine deoxyribonucleosides or the base analogue 5‐fluorodeoxyuridine did not increase the uptake of labelled material from thymidine. Growth inhibition which was observed upon the addition of deoxyadenosine, 5‐fluorodeoxyuridine or 5‐fluorouracil has been discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
