Abstract
Investigations of antigens from three clinically well perfused human kidneys have been performed using xeno‐antibodies of rabbit. The kidney preparations contained immunogenic amounts of normal human serum proteins. After absorption with autologous hepar tissue there were no signs in the absorbed anti‐renal sera of remaining antibodies to serum protein if tested in double diffusion in agar gel. If tested against these hepar absorbed anti‐renal sera, the saline extracted renal specific antigens were found to be thermolabile, trypsinstable and pepsinstable. A kidney cortex extract obtained after heating at pH 2.0 revealed a further antigen cross‐reacting with the thermolabile kidney specific antigens. No indication of individual specificity could be found in double diffusion in gel analysis. The different anti‐renal sera were equally cytotoxic to different human lymphocyte suspensions. The hepar absorbed anti‐renal sera showed weak or non‐lymphocytotoxic reactions to different human lymphocyte suspensions.
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