Utilization of the Sex-Linked Gene for Imperfect Albinism (S*ALS).: 1. Effect of Early Weight Loss on Chick Metabolism

Abstract

The sex-linked gene for imperfect albinism (S*ALS) has been associated with slow early growth in some trials but not in others. Albino (59) and nonalbino (73) chicks were raised to 3 d of age to study early growth. At 3 d of age, plasma β-hydroxybutyrate (β-HBA) levels were measured and the chicks were euthanatized and dissected to measure liver, gall bladder, and yolk sac weights. Fatty acids of the liver and the yolk sac were also analyzed. On average, albino chicks lost weight between hatch and 3 d of age and nonalbinos gained weight (−2.41 vs 0.74 g/d, P < 0.01). At 3 d of age, livers from albinos contained higher (P < 0.01) levels of docosahexaenoic acid than those of nonalbinos, likely reflecting the dependence on yolk sac nutrients of albinos and on dietary lipids of nonalbinos at this time. Albinos had lower body temperatures (P < 0.01), liver weights (P < 0.01) and gall bladder weights (P < 0.05), and heavier yolk sacs (P < 0.01) than did nonalbinos. Plasma levels of β-HBA were higher (P < 0.01) for albinos than for nonalbinos. At similar body weights, chicks of both genotypes had similar body temperatures, gall bladder weights, and plasma β-HBA levels. Linear regressions indicated that in albinos weight loss is associated with larger yolk sacs, smaller livers, larger gall bladders, lower body temperatures, and higher levels of β-HBA. Yolk sac utilization seemed to be correlated with activation of the digestive system. The inability of starving chicks to use the yolk sac nutrients while lipolysis is taking place suggests that yolk sac absorption does not respond to lipolytic hormones. Because under certain conditions a large proportion of albinos (90% in this experiment) show the symptoms of the starve-out syndrome, the S*ALS gene could serve as a model for the study of this syndrome.