Abstract
In modern drug discovery techniques consistently increasing in the number of new pharmacologically active lipid compounds these compounds are poorly water-soluble. A great challenge of making this medication for oral administration with the desired bioavailability. Epilepsy is a severe neurological disorder that needs rapid treatment. To enhancement of its bioavailability, we need to make lipid-based drugs. On other hand, the surface tension reducing agents will give poor water-soluble formulation. Treatment of Neurological disorder is still a challenge for medical practitioners because of restricted moments and barriers. The solid lipid nanoparticles (SLN) and nanoemulsions are easily avoided the blood-brain barrier. Therefore, there is a maximum therapeutic efficacy achieved by using the lipid and polymer-based drug delivery system in the treatment of neurological disorders.
 Keywords: Neurological disorder, Lipid, Polymer, Lipid Based Drug delivery systems, Epilepsy, Treatment.
Highlights
Many neurological disorders are seeking treatments and in most of the neurologic diseases based on the hypersynchronous activity of the neurons in the cerebral cortex or neurochemical imbalance in the brain
Lipid and polymer delivery systems leading from front because of its higher advantages & numerous biocompatibilities. [30,31,32,33,34-40] To meet a wide range of product requirements these formulations can be modified in various ways per the disease condition, route of administration, and cost product stability, toxicity, and efficacy
Lipid and polymer delivery systems can be developed successfully by consideration of the following formulation objectives In which selection of excipients based on their melting point and fatty acid composition, HLB value, disposability, and digestibility; proper screening of required excipients for appropriate solubility, dispersion & dissolution properties, which must be compatible with API and able to enhance the stability of formulation design of proper animal models to evaluate in vivo performance of the chosen formulation and improve the formulation with the proper drug loading and dissolution profile.[69,70,71,72]
Summary
|| Print ISSN: 2589-7837 || Online ISSN: 2581-3935 || International Journal of Medical Science and Diagnosis Research (IJMSDR). Available Online at www.ijmsdr.com NLM (National Library of Medicine ID: 101738824) Volume 4, Issue 11; November: 2020; Page No 01-06. UTILIZATION OF POLYMER AND LIPID-BASED DRUG DELIVERY SYSTEMS IN TREATMENT OF NEUROLOGICAL DISORDERS- A MINI REVIEW Arsalan Sarmad Department of Pharmacology, Lovely Professional University Paghwara, Punjab, India.
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