Abstract
Pharmaceutical technology offers various dosage forms that can be applied interdisciplinary. One of them are spherical pellets which could be utilized as a carrier in emerging second-generation detection tubes. This detection system requires carriers with high specific surface area (SSA), which should allow better adsorption of toxic substances and detection reagents. In this study, a magnesium aluminometasilicate with high SSA was utilized along with various concentrations of volatile substances (menthol, camphor and ammonium bicarbonate) to increase further the carrier SSA after their sublimation. The samples were evaluated in terms of physicochemical parameters, their morphology was assessed by scanning electron microscopy, and the Brunauer–Emmett–Teller (BET) method was utilized to measure SSA. The samples were then impregnated with a detection reagent o-phenylenediamine-pyronine and tested with diphosgene. Only samples prepared using menthol or camphor were found to show red fluorescence under the UV light in addition to the eye-visible red-violet color. This allowed the detection of diphosgene/phosgene at a concentration of only 0.1 mg/m3 in the air for samples M20.0 and C20.0 with their SSA higher than 115 m2/g, thus exceeding the sensitivity of the first-generation DT-12 detection tube.
Highlights
IntroductionPharmaceutical technology methods are often based on principles transferred from other industries, but they are improved and more accurate because drugs have to meet much stricter quality standards
The presence of metasilicate was expected to be essential, which was supposed to be determined by comparing the samples with modified specific surface area (SSA) (M7.5–20.0, C7.5–20.0 and AB7.5–20.0) with a blank sample without volatile substances (VSs) and Neusilin® US2, and with a second blank sample without
Such pellets have great potential across many scientific fields because, in addition to possible traditional pharmaceutical applications, for example, when the carriers are loaded with a drug, they could potentially provide immediate release, as was tested in other studies with different porous pellets [37,38]; they could be used in analytical detection systems such as detection tubes
Summary
Pharmaceutical technology methods are often based on principles transferred from other industries, but they are improved and more accurate because drugs have to meet much stricter quality standards. One of these methods, originally from the food industry, is extrusion/spheronization [1]. Originally from the food industry, is extrusion/spheronization [1] This method produces highly spherical particles called pellets with a uniform shape and particle size distribution [2]. Such pellets have suitable properties for drug sorption and subsequent controlled release [3]. In some countries, they are used as carriers in detection tubes, 4.0/)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
