Abstract
The transfer of ingested dehydroisoandrosterone sulfate (DS) to systemic circulation was measured in two normal pregnant women, in one adrenalectomized pregnant woman and in one non-pregnant woman, by oral administration of 14C-labeled or unlabeled DS and by intravenous injection of tritiated DS. The isotope ratios in urinary DS, and the decrease in the specific activity of this metabolite with the ingestion of DS, indicated that more than 60 per cent of the ingested steroid appeared in the bloodstream. The placental conversion of DS to estrogens was unaffected by the increased amounts of circulating DS. Consequently, ingestion of DS resulted in significant increases in the rate of production and urinary excretion of estro-gens. An adrenalectomized pregnant patient at term increased her sub-normal rate of production of estrone plus estradiol (5 mg/day) to 16 mg/day by ingesting 60 mg of DS daily.
Published Version
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