Utilization of date products in production of oxytetracycline by Streptomyces rimosus.

Abstract

The carbon and nitrogen sources of a synthetic fermentation medium were substituted by equivalent amounts of date-coat sugar extract and date-seed hydrolysate. The addition of 1.0 g dm-3 urea and date-seed lipid into the medium increased the efficacy for antibiotic formation. When the MgSO4, MnSO4, FeSO4 and ZnSO4 components of the medium were replaced by 0.5 g dm-3 date-seed ash, antibiotic output was also increased.