Abstract
Problem statement: This study presents rapid, uncomplicated and sensitive spectrophotometric techniques for the analysis of doripenem in both its pure and pharmaceutical forms. Approach: The main principle of the approaches and procedures that have been developed is the reaction of doripenem as an n-electron donor to ninhydrin and π-acceptors, such as tetracyanoethylene, 7,7,8,8-tetracyanoquinodimethane, 2,3,5,6-tetrachloro-1,4-benzoquinone, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and chloranilic acid. The wavelengths 580, 264, 320, 357, 375 and 465 nm was used for measuring the resulting complexes for ninhydrin, chlorine, chloranilic acid, DDQ, TCNQ and TCNE respectively. Results: The suggested procedures for the determination of doripenem were successfully put into practice with good recovery; the percent recovery ranged from 99.31-100.55. Benes-Hildebrand plots were also used to study the association constants and the free energy changes. Conclusion: The results of the CT method agree with those of the kinetic method and there is no significant difference between them.
Highlights
Meropenem (Horiuchi et al, 2006)
This study suggests that simple and sensitive spectrophotometric procedures may be used for the
Reaction with π-acceptors: An intense coloration was produced by mixing the doripenem solution (Lewis base) and the π-acceptor solutions (Lewis acid) in an acetonitrile medium at room temperature, which indicates the formation of a CT complex
Summary
A literature survey reveals the use of only high-performance Doripenem (S-4661) is a novel carbapenem with liquid chromatography for the determination of antibacterial activity against a broad range of Gram- doripenem. Ertapenem and biapenem, doripenem has a 1-β-methyl group, hindering attack by renal dehydropeptidase (Mori et al, 1996) and unlike imipenem, does not need to be protected with a dehydropeptidase inhibitor. Ultraviolet spectrophotometry (first-derivative, first-derivative of ratio spectra and bivariate analysis) was used in the stability-indicating determination of ertapenem (Zajac et al, 2006; 2007; Hassan et al, 2009), meropenem (Elragely et al, 2008; Mendez et al, 2003) and doripenem (Piontek and Jelinska, 2010). The methods are based on the reaction of the primary amino group of doripenem with ninhydrin and π-acceptors
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
