Abstract
Abstract A lipase-catalyzed direct Mannich reaction of arylamines with aromatic aldehydes and ketones including cyclohexanone, butanone and 1-hydroxy-2-propanone was developed under EtOH/H2O system in a “one-pot” strategy. A series of experiments on the promiscuous activity of lipases were performed to optimize the biocatalytic process, and a wide scope of substrates was expanded with good yields.
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