Abstract
Abstract A systematic solvent selection method is used for the development of HPLC conditions for the separation and detection of trace amounts of threo isomer in samples of the bronchodilating drug procaterol, (±)-(R∗, S∗)-8-hydroxy-5-[1-hydroxy-2-[(1-utethyl-e thyl)amino]butyl]-2(1H)-quinoline (erythro isomer). The method involves the chromatography of a mixture of the two isomers using seven different mixtures of three base solvents as mobile phases and the mapping of resolutions using a computer-generated mathematical model. The optimized mobile phase predicted by the model gives excellent resolution between the two isomers at levels as low as 1% of the threo compound.
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