Abstract
In recent years, the paradigm of toxicity science is moving toward predictive science. New approach methodologies (NAMs), including <i>in chemico</i>, <i>in silico</i>, and <i>in vitro</i> approach, provides a new feasibility to minimize the whole animal toxicity testing. To support these efforts, the U.S. Environmental Protection Agency (EPA)’s web-based CompTox Chemical Dashboard was developed and providing relevant data through a curation of diverse substances and predictive tools. In this review, we presented a comprehensive analysis of EPA CompTox Chemical dashboard’s available data, predictive tools and recent case studies using them. We also suggested a perspective of utility of EPA CompTox Chemical Dashboard for implementation of next generation risk assessment and toxicity prediction of environmental chemicals.
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