Utility of different body composition for the predicting myocardial ischemia in the type 2 diabetes mellitus(T2DM)patients

Abstract

Objective To explore the utility of different body composition for the prediction of myocardial ischemia in exercise in type 2 diabetes mellitus(T2DM)patients. Methods T2DM outpatients were selected from Jul. 2013 to Nov. 2014(male 83, female 57)to measure body composition and clinical biochemical parameters, and divided them into two groups according to treadmill exercise testing results. Group A cases were positive(27 patients)and Group B cases were negative(113 patients). SPSS19.0 was used to make statistical analysis. Results (1)The age, gender, diabetes mellitus(DM)duration, medical history of hypertension and dyslipidemia, body mass index(BMI), waist circumference, the waist-hip fat ratio of the two groups had no significant difference(P>0.05).(2)The fasting blood glucose(FBG), glycosylated hemoglobin(HbA1c), total cholesterol(TC), triglycerides(TG), high density lipoprotein cholesterol(HDL-C)between the two groups had no significant difference. Compared with group B, the low density lipoprotein cholesterol(LDL-C)of group A[(2.48 ± 0.75)mmol/L vs.(2.81 ± 0.77)mmol/L, t=2.009, P<0.05]decreased significantly.(3)Overall body fat percentage, skeletal muscle weight of the two groups had no significant difference. Compared with group B, the waist-hip fat ratio(0.93±0.06 vs. 0.88±0.08, t=-2.790, P<0.01)and visceral fat area[(99.47 ± 32.84)cm2vs.(81.10 ± 25.47)cm2, t=- 2.822, P<0.01]of group A increased significantly, while this difference mainly existed in male patients visceral fat area[(100.99±39.33)cm2vs.(79.91 ± 27.09)cm2, t=- 2.231, P<0.05], and waist-hip fat ratio was different in female patients of the two groups(0.91±0.06 vs. 0.85±0.09, t=-2.043, P<0.05). Conclusion Abdominal obesity, especially visceral fat accumulation had close correlation with myocardial ischemia in exercise in T2DM patients. Waist-hip fat ratio and visceral fat area may be more effective indicators of myocardial ischemia in exercise in T2DM patients than BMI. Key words: Diabetes mellitus, type 2; Body composition; Macroangiopathy; Exercise tolerance test