Abstract

目的: 探讨延胡索酸水合酶(fumarate hydratase,FH)缺陷型子宫平滑肌瘤的临床病理学特征。 方法: 复习2008年9月至2018年6月广西壮族自治区人民医院诊治的3例FH缺陷型子宫平滑肌瘤临床病理资料,用免疫组织化学方法检测肿瘤组织FH表达状况。 结果: 3例患者均为年轻女性。形态学表现为肿瘤细胞具有不典型性,可出现明显的嗜酸性大核仁、核周空晕、嗜酸性胞质内小球及鹿角状血管。免疫组织化学染色显示肿瘤细胞FH表达缺失。 结论: FH缺陷型子宫平滑肌瘤具有特征性形态学表现,肿瘤细胞具有不典型性,易过诊断为恶性潜能未定平滑肌肿瘤或平滑肌肉瘤,免疫组织化学染色可协助诊断。.

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