Uterine Anomalies Associated With Intrauterine Growth Restriction and Hypertensive Disorders During Pregnancy [40K

Abstract

INTRODUCTION: Congenital anomalies of the uterus have a worldwide prevalence of 2-4% in women of reproductive age, the associated perinatal outcomes are recurrent gestational loss, preterm birth, and anomalous presentations with increased risk of caesarean section. Smaller studies have suggested the link between hypertensive disorders, intrauterine growth restriction and uterine anomalies. The purpose of this study was to compare the rate of hypertensive disorders and intrauterine growth restriction in pregnant women with a known uterine anomaly to the rate in the normal pregnant population. METHODS: A population-based retrospective cohort of all live births in Institute of Perinatology (2018-2019) was analyzed. Clinical characteristics of patients who were gravid for more than 28 weeks, and had an uterine anomaly. The rate of hypertensive disorders and intrauterine growth restriction among women with uterine anomalies was calculated and compared among women without uterine anomalies. RESULTS: From January 1, 2018 to July 7, 2019, there were 95 women seen in our third level center who were gravid for more than 28 weeks and had a uterine anomaly. A greater proportion of women with a uterine anomaly had a hypertensive disorder (6.3%) and intrauterine growth restriction (11.5%) than women without a uterine anomaly (3.0%) (P=.001) and 6% 8 (P=.001) respectively. CONCLUSION: The prevalence of pregnancies with uterine abnormalities is increasing. Understanding the specific pregnancy outcomes that are associated with these high risk pregnancies will be crucial for appropriate management and multidisciplinary to avoid adverse perinatal outcomes.