Abstract
The microfluidics is a technology of systems that manipulate and study small amounts of fluids, by means of structures with dimensions of tens to hundreds of micrometers (microdevices), having as main advantage its minimum cost, speed, and ability to provide on-the-spot results. In this work, the microfluidics paper version, which is considered the cheapest, was developed to carry out the Fast Blue b salt reaction in order to calculate the cannabinol (CBN) content in seized marijuana samples (n = 66). The aim is to use knowledge of the conversion reactions of other cannabinoids to CBN to discover the temporal traceability of samples exposed to the environment. To build the quantification model, a smartphone camera combined with the Photometrix® application was used. The analytical curve constructed for CBN determination showed a coefficient of determination (R2) = 0.9964 and Root Mean Square Calibration Error, RMSEC, = 0.576 for quantification by microfluidics, and R2 = 0.9947 for quantification by liquid chromatography. For seized marijuana samples, CBN concentrations ranged from 8.97 to 21.48 mg mL-1 with an average value of 14.11 mg mL-1, being quantified by colorimetry associated with chemometric tools. With all the information obtained, it was also possible to evaluate the time of environmental exposure, which can be discussed in view of these concentrations and knowledge of the samples, allowing their traceability. Finally, the quantification was repeated in the traditional way, e.g., HPLC-DAD, in order to confirm the values found.
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