Abstract
Based on the concept that the specificity and affinity of antibody-antigen binding are dependent on 3-D structural fit between the antigenic epitope and the antibody variable region, site-specific monoclonal antibodies (mAbs) can be used as probes to detect the allosteric conformation and changes of a target protein. Unlike traditional methodologies such as fluorescence labeling which may alter the native state of a protein, the mAb approach can be utilized free of protein modification using relatively small amounts of the target protein under physiological conditions.
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