Abstract
The ability of MRI to provide three dimensional images of thick opaque samples in a noninvasive manner has made it an extremely important clinical tool. In addition, the large number of types of contrast mechanisms in a MR experiment offer the clinician and research scientist the possibility of adapting the image contrast to fit the problem of interest. While typical resolutions employed clinically are on the order of a millimeter, the notion of using MRI at microscopic resolutions arose early in the development of this technique. Spatial resolution in biological samples is typically limited by a number of physical effects as well as signal-to-noise ratio (S/N) considerations. Estimates of the theoretical limits of resolution in the MR image arising from these phenomena range from 2 to 0.5 micron. The practical spatial resolution is currently determined by the S/N which is often limited by the amount of time available to actually acquire the image (i.e. the temporal resolution).
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