Using certain indices of fibrinolytic system for forecasting the efficiency of neoajuvant chemotherapy in ovarian cancer.

Abstract

e22022 Background: Using cell markers that characterize biological properties of a tumor, the relevance of treatment used can be determined for each patient, further ways of surveillance of the patients can be selected, and individual forecasts of the illness can be made. Methods: After 1 course of neoajuvant chemoterapy according to the scheme CAP, in the malign tumor tissue of 21 patients (T3a-c N0-1M0-1), the activity of plasminogen and plasmin was determined by ELISA. Then the ratio K of plasminogen (PG) and plasmin (P) was calculated. As a blank, tumor tissue of 18 patients having ovarian cancer without chemotherapy administered has been studied. On all patients, operations in full or cytoreductive surgery were performed. Results: With efficient treatment, ratio K increased (К=1,4±0,2) relative to indices in patients without neoajuvant chemotherapy (К=0,3±0,17), while it remained the same (К=0,2±0,09) or decreased relative to initial data if there was no clinical effect, which is confirmed by further development of ovarian cancer. Conclusions: Thus, determining of plasminogen and plasmin – fibrinolytic system indices – in the tumor tissue and calculating of their ratio allows detecting the patients who have effect from treatment and good forecast and ones without effect, having bad forecast, who need aggressive ajuvant treatment. It also allows determining individual sensitivity or resistance of malign tumors in patients to certain regimens of chemotherapy. At the same time, there is an opportunity to objectify the results of specific therapy.