USING 4-[18F]-ADAM MEASURE SEROTONIN TRANSPORTER VARIATIONS WITH HAMD SCALE RELATED TO MAJOR DEPRESSIVE DISORDER IN CT/PET THREE-DIMENSIONAL IMAGE

Abstract

The medical image can be divided into two major classes: anatomical image and functional image. Magnetic resonance image (MRI) and computed tomography (CT) belong to the anatomical image, which can show an outline of an organ and a tissue clearly. The functional image can show the image of the organ and the tissue metabolism situation. Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are also part of the functional image. In this paper, we use 4-[[Formula: see text]F]-ADAM to measure serotonin transporter changes and find the relation with major depressive disorder in CT/PET three-dimensional image. In clinical diagnosis, based on the video imaging methods can be divided into the anatomy and function of these two categories. Therefore, the combination of anatomical and functional imaging can provide more useful information. In the study, we use the CT image to get the reference position and combine it with the isotope metabolic situation from PET. We use the fused image to construct 3D image and count serotonin transporter with different times, and measure the variance about serotonin transporter changes in the organization of the metabolism and distribution. We use the variance to find the relation and compare the score using Hamilton Depression Rating Scale by experienced psychiatrists. After the test cases, we measure the serotonin transporter distribution of depressed patients can do a preliminary classification. We can get the gray-level value changes in major depressive disorder patients at different times. The advantage of this method is to offer more information to diagnose or analyze the difference between the brain organs, such as pons, midbrain, thalamus, corpus striatum, and prefrontal cortex.