Abstract
The medical image can be divided into two major classes that are anatomical image and functional image. Magnetic resonance image (MRI) and computed tomography (CT) belong to the anatomical image, which can show an outline of an organ and a tissue clearly. The functional image can show the image of the organ and the tissue metabolism situation. Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are also part of the functional image. In this paper, we use 4-[18F]-ADAM to measure serotonin transporter changes and find the relation with major depressive disorder in CT / PET three-dimensional image. In clinical diagnosis, based on the video imaging methods can be divided into the anatomy and function of these two categories. Therefore, the combination of anatomical and functional imaging can provide more useful information. In the study, we use CT image to get the reference position, and combine with isotope metabolic situation from PET. We use the integrated image to do 3D image and count serotonin transporter with different points in time, and measure the variance about serotonin transporter changes in the organization of the metabolism and distribution. We use the variance to find the relation and compare the score using Hamilton Depression Rating Scale by experienced psychiatrists. After the test case, measuring the size distribution of serotonin transporter to depression patients can do a preliminary classification.
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