Abstract
BackgroundTo evaluate the clinical significance of Mac-2 binding protein glycosylation isomer (M2BPGi), we investigated the relationship between M2BPGi and clinicopathological and surgical parameters and posthepatectomy complications.Materials and methodsWe examined M2BPGi in 115 patients with hepatic malignancies undergoing hepatectomy. Significance as an independent prognostic marker was determined with multivariate logistic regression analysis.ResultsThe mean serum M2BPGi level was 1.14 ± 1.03 C.O.I. (range 0.2–5.79). M2BPGi in the chronic viral hepatitis group (1.42 ± 1.25) was significantly higher than that in the other disease groups (p < 0.05). The M2BPGi level correlated negatively with platelet count, LHL15 and GSA-Rmax (r = −0.36, −0.69 and −0.56, respectively; p < 0.01) but correlated positively with serum hyaluronate level (fibrotic marker), ICGR15 and HH15 (r = 0.52, 0.63 and 0.57, respectively; p < 0.01). In 53 patients examined for histological hepatic fibrosis, the M2BPGi level was highest for hepatic fibrosis stage 4, indicating cirrhosis (2.15 ± 1.56), and was significantly higher than that for stages 0–2 (p < 0.05). M2BPGi level did not correlate significantly with any surgical parameters. The preoperative level correlated significantly only with increased alanine aminotransferase level (r = −0.21, p < 0.05) and was significantly higher in patients with (1.35 ± 0.78) than without (1.11 ± 1.07) hepatectomy-related complications (p < 0.05). Area under the ROC curve analysis for prediction of hepatic fibrosis score 4 showed a cut-off value of 0.78 for M2BPGi to have high sensitivity (90%) and specificity (58%). For postoperative hepatectomy-related complications, only the M2BPGi level (at a cut-off value 0.90) tended to show significance (p = 0.06).ConclusionsThe non-invasively measured serum level of M2BPGi reflected impaired liver function or cirrhosis and hepatectomy-related complications after surgery, making it potentially useful as a complementary parameter accompanying other liver function parameters.
Highlights
Hepatic resection is a useful radical treatment for various liver diseases [1,2], but background liver functional reserve or pathogenesis typically results in hepatic failure, uncontrolled ascites or surgical site infections [3,4]
LHL15 and galactosyl serum albumin (GSA)-Rmax were significantly lower in the patients in the chronic viral hepatitis group than in those in the other groups (p < 0.05)
Serum Mac-2 binding protein glycosylation isomer (M2BPGi) serves as a fibrotic marker by detecting the alteration of glycoprotein caused by liver fibrosis as described above, which can be measured within 20 min using the presently available assay kit [20]
Summary
Hepatic resection is a useful radical treatment for various liver diseases [1,2], but background liver functional reserve or pathogenesis typically results in hepatic failure, uncontrolled ascites or surgical site infections [3,4]. Some investigators including our group have reported that a serum marker such as hyaluronic acid level is a useful predictive marker for uncontrolled ascites or hepatic failure [11,12]. In 53 patients examined for histological hepatic fibrosis, the M2BPGi level was highest for hepatic fibrosis stage 4, indicating cirrhosis (2.15 ± 1.56), and was significantly higher than that for stages 0–2 (p < 0.05). For postoperative hepatectomy-related complications, only the M2BPGi level (at a cut-off value 0.90) tended to show significance (p = 0.06). Conclusions: The non-invasively measured serum level of M2BPGi reflected impaired liver function or cirrhosis and hepatectomy-related complications after surgery, making it potentially useful as a complementary parameter accompanying other liver function parameters. Functional liver reserve Platelet count (/mm3) Prothrombin activity (%) Total bilirubin (mg/dL) Serum hyaluronic acid level (mg/dL) ICGR15 (%) LHL15 HH15 GSA-Rmax (mg/mL). Postoperative liver functionsb Total bilirubin level (mg/dL) Aspartate aminotransferase (IU/L) Alanine aminotransferase (IU/L) Prothrombin activity (%) Platelet count (104/mm3) C-reactive protein (mg/dL)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
