Usefullness of a Combined Evaluation of the Serum Adiponectin Level and Insulin Growth Factor 1 to Predict the Early Stage of Nonalcoholic Steatohepatitis

Abstract

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western industrialised countries and affects around 25% of the European population. The prevalence of NAFLD is increasing in parallel with the global increase in obesity and type 2 diabetes mellitus (T2DM). Aim of the Work To investigate the role of adiponectin and IGF1 in the diagnosis of NASH. Patients and Methods The present study included 60 patients who attending the outpatient clinic of Ain Shams University hospital, they age ranges from thirty to sixty years. Results It was found that highly significant decrease in Adiponectin and IGF-1 levels, in NASH group; compared to NAFLD control group (p < 0.01 respectively) a This data is similar to many studies done before in NAFLD and NASH patients. Our study also shows that; AST, ALT, total and direct bilirubin, had a highly significant negative correlation with IGF-1 and Adiponectin level (p < 0.01 respectively). This go with many studies who found a significant inverse correlation between IGF-I levels and liver enzymes, indicating that lower IGF-I levels in NAFLD are related to parenchymal dysfunction. With proven evidence that low circulating IGF-I levels correlate with the degree of liver dysfunction. Conclusion Serum adiponectin and insulin growth factor 1 are lower in patients with NASH compared to NAFLD patients which reflect the protective effect of both of adiponectin and IGF1 against the development of NASH.