Use of vitamin K1 in pregnancy: Effect on serum bilirubin and plasma prothrombin in the newborn

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In general, from this double blind study of 204 infants it appeared that prenatal oral administration of vitamin K 1 exerted a beneficial effect on the relative deficiency of prothrombin that normally exists in the newborn infant. There was no evidence of undesirable side effects from doses of vitamin K 1 employed in this study. Bilirubin levels in the newborn infants receiving vitamin K 1 were not increased over the values in the placebo group. It is not possible to conclude from these data that such treatment is to be generally endorsed.