Use of the Comprehensive Geriatric Assessment (CGA) in elderly patients (pts) with solid tumors to predict mortality

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9549 Background: The internet based IN-GHO-Registry, a project of the Initiative for Geriatric Hematology and Oncology, supported by ORTHO BIOTECH, Division of Janssen-Cilag GmbH, Germany, prospectively collects data of elderly cancer pts. We report data from 1130 pts with solid tumors. Results of a CGA, physicians' and pts' judgement of fitness were studied in relation to mortality within 5–7 months. Methods: Demographic data, data on activities of daily living (ADL), instrumental activities of daily living (IADL), Karnofsky-Performance-Statuts (KPS), comorbidity (Charlson score), number of co-medication, mobility (Timed-Up&Go), cognition (MMSE), and depression (SCID screening) were collected. Age, results of CGA, physicians' rating (fit vs compromised vs frail) and pts' self rated fitness for treatment (Likert scale 1= very fit to 6 = very unfit) were analysed for association with death. Follow-up (FU) was scheduled 5–7 months after inclusion. Results: 1130 pts, mean age 76.3 years (SD 4.7; range 69–95), 44% male, were included. Main diagnoses were gastrointestinal tumors (38%), breast cancer (12%), and lung cancer (11%). Physicians rated 58% of pts fit, 37% compromised, and 5% frail. Pts' self rating of fitness: 1 = 19%, 2 = 30%, 3 = 28%, 4 = 17%, 5 = 5%, 6 = 1%. During FU (median 177 days), 272 pts (24%) died. Mean age (76.5 vs. 76.3; p=0.75) was not associated with death. However, sex (male vs female, p<0.001), BMI (24.4 vs 25.9; p<0.001), Charlson-score (6.3 vs 5.5; p<0.001), number of co-medication (4.5 vs 3.7; p<0.001), ADL score (87.9 vs 93.9; p<0.001), IADL score (6.2 vs 7.0; p<0.001), KPS score (75% vs 83%; p<0.001), MMSE (25.6 vs. 26.2; p=0.045), categorical Timed-Up&Go (less than 10s, 10–20s, more than 20s; p<0.001), categorical SCID (0, 1, 2; p=0.012), physicians' rating of fitness (fit, compromised, frail; p<0.001) and mean pts' rating of fitness (3.1 vs. 2.4; p<0.001) were significantly associated with death during FU. Conclusions: Pts characteristics as assessed by CGA and not age are associated with death in elderly pts with solid tumors. [Table: see text]