Abstract
In modern times, people are suffering from many mental health disorders like schizophrenia, bipolar disorders and many psychoses. Hence, it is essential to treat these mental disorders using medications as well as with assistance from caregivers for the social well being of person. This study was focussed on improving solubility & dissolution of poorly soluble drug Ziprasidone using different formulation approaches like solid dispersion & inclusion complexation. Different solubility enhancing techniques like physical mixing, solvent evaporation, microwave irradiation, lyophilization & spray drying were used for the along with four different polymers i.e Kollidon, Soluplus, Pluronic and HPβCD. The prepared formulations were evaluated for saturated solubility, dissolution, ATR, SEM, XRD, pharmacodynamic and pharmacokinetic in vivo study. The prepare formulations showed increment in solubility as well as dissolution. The order of solubility enhancement for the studied polymers was found to be of following order: Soluplus >HPβCD >Kollidon >Pluronic. In the pharmacodynamic study, the optimized solid dispersion showed the calming effect on mice when compared to pure Ziprasidone. The pharmacokinetic study demonstrated the increase in oral absorption of Ziprasidone in all prepared formulations and it followed the same order as that solubility & dissolution enhancement. The Soluplus-solid dispersion prepared by spray drying technique was found to be suitable in enhancing oral absorption with significant (p < 0.05) enhancement in Cmax & AUC than pure Ziprasidone. Hence, comparative study was helpful in increasing oral bioavailability Of Ziprasidone in choosing the suitable polymer with decreasing the dose and increasing patient adherence to therapy.
Highlights
World health organization’s (WHO) 66th World Health Assembly has supported “Mental Health Action Plan 2013-2020” which is very essential for the social well being of people suffering from mental disorders like schizophrenia, bipolar disorders, depression etc. in the world
The saturation solubility of solid dispersion by spray drying with Kollidon, Soluplus, Pluronic (F-127) in distilled water was found to show, an almost 13.7, 17.1, 8.59 fold increase in solubility respectively than pure drug
The drug to polymer ratio affects the solubility of Ziprasidone, optimum ratio was selected based on solubility enhancement [57]
Summary
World health organization’s (WHO) 66th World Health Assembly has supported “Mental Health Action Plan 2013-2020” which is very essential for the social well being of people suffering from mental disorders like schizophrenia, bipolar disorders, depression etc. in the world. The formal step taken by WHO representing the need of addressing the mental health disorders faced by today's world [1, 2]. There are many Mental health disorders that world is facing like depression, bipolar disorder, schizophrenia & other psychoses, dementia, cognitive disabilities as well as developmental disorders like autism. Schizophrenia is a mental disorder affecting severely, defined by intense disturbance in thinking, language, emotion, basic cognitive process & consciousness. It involves psychotic experiences, like hearing voices or delusions. It is affecting performances at various social and work levels. Journal of Drug Design and Medicinal Chemistry 2017; 3(3): 37-48
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