Use of Semen Quality to Predict Pregnancy in Couples Undergoing ICSI

Abstract

The objective of this study was to determine how fertilization, implantation and pregnancy depend on two basic sperm parameters, sperm concentration and sperm motility in ICSI procedure. Primary outcome as fertilization rate (FR), implantation rate (IR), βhCG/cycle, clinical pregnancy rate (PR) and live births rate (LBR) to be stated. In our center 44 cycles of ICSI were carried out in natural and stimulated cycle. Male subfertility was defined as semen quality not meeting the criteria for normality as defined by the World Health Organization (WHO, 1999). FR, IR, βhCG/cycle, PR and LBR were not significantly different between the 5 form male subfertility (normo-, oligo-, astheno-, oligo-astheno- and oligoasthenoteratozoospermia) in ICSI (P < 0.05). In oligoasthenoteratozoospermia IR, βhCG/cycle, PR and LBR was higher than in other cases. The best results are achieved in the case of fertilization rate. PR and LBR had the lowest values in the case oligoasthenozoospermia. In normozoospermia were extremely low values PR and LBR. The only factor that obviously impacts on ICSI-related pregnancy is maternal age, impairing oocyte/embryo quality. The answer to the question of how to predict and increase the success of the ICSI procedure should be sought in assessment of sperm DNA integrity.