Abstract
Resveratrol, a polyphenolic compound found in blackberry and red wine, has properties that prevent the development of atherosclerosis, and therefore, cardiovascular disease. The aim of this study was, through a systematic review, to assess whether resveratrol reduces the incidence of cardiovascular events and improves inflammation and endothelial dysfunction in individuals at risk. Searches were conducted in databases such as LILACS, PubMed,SCIELO and selected randomized controlled trials in humans, including the use of resveratrol in the prevention of cardiovascular events or in the improvement of inflammation and endothelial function. The final sample consisted of 10 items. Of the four studies that analyzed the flow-mediated dilatation of the brachial artery, all showed significant improvement in endothelial function after the use of resveratrol, compared with placebo.In the 7 studies that evaluated subclinical inflammation, there were differences, 3 studies showed significant decreases in the values of TNF-α, 2 showed significant changes in plasma levels of C-reactive protein and interleukin 6 (IL-6), while 1 didn't showed changes in TNF-α and IL-6. In conclusion, resveratrol is capable of improving endothelial function when compared with placebo. However, it was not possible to infer an improvement or not in the parameters concerning endothelial inflammation, since the data extracted from the studies were insufficient. Moreover, it was not possible to evaluate the use of resveratrol in the improvement of survival, infarction or reduction in mortality, since there were no records in the literature of randomized controlled trials that analyzed the effect of resveratrol use on clinical outcomes in humans.
Highlights
METHODSCardiovascular Diseases (CVD) are the main cause of death in in developed countries with atherosclerotic disease being considered a public health problem[1,2]
Atheromatous plaque formation results from a response to tissue lesions triggered by the endothelium, probably due to the accumulation of low density lipoprotein (LDL), which is later oxidized[5,6]
Resveratrol, a polyphenolic compound found in grape skins, red wine, eucalyptus and peanuts is found, whose benefits have become recognized worldwide, due to its antioxidant and anti-inflammatory properties, in addition to the capacity to inhibit LDL oxidation, and stimulate nitric oxide (NO) production, which characterize it as a cardiovascular protector[8]
Summary
METHODSCardiovascular Diseases (CVD) are the main cause of death in in developed countries with atherosclerotic disease being considered a public health problem[1,2]. The aim of the present study was to evaluate the effect of the use of resveratrol on the prevention of cardiovascular events, endothelial function and the inflammatory response in human beings.
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