Use of reduced dose rate when treating moving tumors using dynamic IMRT

Laurence Court,Tania Lingos,Deborah Schofield,Matthew Wagar,Aaron Allan,Madeleine Bogdanov,Ross Berbeco,Dan Ionascu

doi:10.1120/jacmp.v12i1.3276

Laurence Court, Tania Lingos + Show 6 more

Open Access

https://doi.org/10.1120/jacmp.v12i1.3276

Copy DOI

Abstract

The purpose was to evaluate the effect of dose rate on discrepancies between expected and delivered dose caused by the interplay effect. Fifteen separate dynamic IMRT plans and five hybrid IMRT plans were created for five patients (three IMRT plans and one hybrid IMRT plan per patient). The impact of motion on the delivered dose was evaluated experimentally for each treatment field for different dose rates (200 and 400 MU/min), and for a range of target amplitudes and periods. The maximum dose discrepancy for dynamic IMRT fields was 18.5% and 10.3% for dose rates of 400 and 200 MU/min, respectively. The maximum dose discrepancy was larger than this for hybrid plans, but the results were similar when weighted by the contribution of the IMRT fields. The percentage of fields for which 98% of the target never experienced a 5% or 10% dose discrepancy increased when the dose rate was reduced from 400 MU/min to 200 MU/min. For amplitudes up to 2 cm, reducing the dose rate to 200 MU/min is effective in keeping daily dose discrepancies for each field within 10%.PACS number: 87.55Qr

Highlights

Several authors have studied the dose discrepancies caused by the interplay between moving radiation fields and respiratory-induced motion of the tumor
It can be seen that the plans have a large average MLC separation, much larger than the 1 cm minimum suggested in published work to minimize the interplay effect
The IMRT fields provided an average of 42% of the total dose

Summary

Introduction

Several authors have studied the dose discrepancies caused by the interplay between moving radiation fields (as with dynamic IMRT [sliding window]) and respiratory-induced motion of the tumor. It has been shown that certain combinations of MLC sequence and target motion can give large dose discrepancies[1,2] for individual fractions. 1. Choose gantry and collimator angles that will minimize large fluence gradients (e.g., do not have beams for which portions of the field-of-view includes the cord or other critical structures). Choose gantry and collimator angles that will minimize large fluence gradients (e.g., do not have beams for which portions of the field-of-view includes the cord or other critical structures)

Objectives

Methods

Results

Conclusion