Use of proteomics in radiobiological research: current state of the art

Abstract

Biological systems are complex, variable and to a great extent adaptive to environmental and occupational challenge such as ionising radiation, making the mathematical modelling of their behaviour a diYcult task. The required models need to be based on useful experimental data describing global eVects on a cellular, tissue and organ level. High-throughput technologies such as proteomics have been shown to be powerful tools on many areas of modern biology. In radiation biology, especially facing the question of possible adverse health eVects following exposures to low doses of ionising and non-ionising radiation, new and sensitive approaches are slowly gaining support. Epidemiological studies suggest that doses of ionising radiation much lower than previously assumed may cause adverse eVects on human health. However, the epidemio