Use of mifepristone plus misoprostol vs cerviprime plus misoprostol for second trimester abortion: A prospective comparative study

Abstract

Background: The complications of abortion increase with the advancing gestational age. The search for the best and most reliable method for second trimester abortion is still ongoing. A prospective comparative study was conducted at a tertiary care hospital in Delhi from 01 Sep 2017 to 31 Aug 2018 with an aim to find out an effective method of second trimester abortion within reasonable time and fewer complications.Study: A total of 70 patients were studied to compare combination of Mifepristone and misoprostol Vs cerviprime and misoprostol for second trimester abortion. The end point of the study was complete abortion with expulsion of placenta. The Induction abortion interval, success rate, side effects and complications were compared between the two groups.Results: There was a significant difference in the IAI in both the groups. The mean Induction to abortion interval was 10.7 hrs in the Mifepristone + misoprostol group and 13.7 hrs in the Cerviprime + misoprostol group. The success rate was 100% in each arm, none of the patients required hysterotomy. More side effects were seen in the cerviprime + misoprostol group.Conclusions: Mifepristone followed by misoprostol and Cerviprime followed by misoprostol are effective methods for second trimester abortion, but mifepristone + misoprostol has the advantage of having lesser Induction to abortion interval and fewer side effects.