Abstract
Use of left ventricle blood pool oxygenation-sensitive signal intensity as a measure of arterial hemoglobin saturation
Highlights
Oxygenation-sensitive cardiovascular magnetic resonance (OS-CMR) relies on the attenuating effects of deoxyhemoglobin as an intrinsic contrast
When using OS-CMR to assess myocardial oxygenation, failing to account for effects on myocardial oxygen-sensitive signal intensity (OS-SI) due to arterial hemoglobin desaturation could confound results attributed to changes in perfusion and tissue metabolism
Using an animal model we first assessed if arterial saturation can be non-invasively measured using the blood pool signal (SI) in OS-CMR images, and secondly if this effect is relevant for human studies
Summary
Oxygenation-sensitive cardiovascular magnetic resonance (OS-CMR) relies on the attenuating effects of deoxyhemoglobin as an intrinsic contrast. When using OS-CMR to assess myocardial oxygenation, failing to account for effects on myocardial oxygen-sensitive signal intensity (OS-SI) due to arterial hemoglobin desaturation could confound results attributed to changes in perfusion and tissue metabolism. This can be relevant when using breath-holds as a vasodilating mechanism. Using an animal model we first assessed if arterial saturation can be non-invasively measured using the blood pool signal (SI) in OS-CMR images, and secondly if this effect is relevant for human studies
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