Use of hyperthermal heating and intraoperatively administered applicator for the treatment of local malignant tumors

Ilya Vasilchenko,Vladimir Braginsky,Aleksey Osintsev,Vitaly Rynk

doi:10.2298/aoo210518004v

Abstract

This article describes a method for non-contact local hyperthermal heating of patient's tissue using inductive electromagnetic radiation. Aim: The aim of the study was a theoretical and experimental assessment of the thermal and electromagnetic parameters of the proposed method based on heating of intraoperatively administered, personal, tissue-replacing applicator using induction magnetic field. Methods: Theoretical estimates of the thermal and electromagnetic parameters of this method were performed based on heat conduction equations. An experimental study of the process was carried out using originally designed laboratory inverter and confirmed theoretical calculations. Results: The performed assessments and calculations confirmed the possibility of creating clinically effective hyperthermia in the removed tumor bed by the method of local non-contact intraoperative hyperthermia. Conclusion: The proposed method can be used both independently and in combination with chemo- and radiotherapy, thus reducing the risk of recurrence for locally advanced forms of malignant tumors of the oropharyngeal region after surgical treatment.

Highlights

Among malignant neoplasms of the head and neck, cancer of the larynx and laryngopharynx occupy a leading position and account for up to 50% of all cases [1]
In patients with advanced stages (T3 and T4) statistics of five-year survival are below 60% [5, 6]
Complex methods for the treatment of malignant tumors is hyperthermia, when tumor is heated to a temperature of 41-45°C

Summary

Introduction

Among malignant neoplasms of the head and neck, cancer of the larynx and laryngopharynx occupy a leading position and account for up to 50% of all cases [1]. In the last decades significant progress in the treatment of laryngeal cancer has been made, a high probability of five-year survival rate (above 90%) can only be achieved for stages T1 and T2. The most common treatment for patients with advanced-stage III and IV laryngeal tumors is laryngectomy that inevitably leads to loss of organ function and does not exclude relapses. In order to achive this task complex methods have been developed, usually based on combination of surgical treatment (including partial resection) with pharmacological and radiation therapy [7,8,9]. Ultra-high-frequency (UHF) radiation has a slightly higher penetrating power. This advantage is abrogated by a much lower focusing ability. Beside this a common disadvantage of radiation in the UHF or MMW range is overheating of subcutaneous fat, which is characterized (in contrast to muscles) by a higher electrical resistance [12]

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