Abstract
Although the mechanisms of the anticancer effects of hyperthermia have remained obscure, it is now generally accepted that the heating temperature must be at least 41.0°C or greater to achieve cancer regression. Clinically applied thermochemotherapy can be divided into local and total-body hyperthermia (TBHT). Local hyperthermia has been primarily used in the treatment of superficial and localized malignant tumors. Because advanced cancer infiltrates neighboring organs and is often metastatic to other distant organs, TBHT appears to be a reasonable and a promising approach. Although various methods for TBHT have been reported, we have been performed TBHT using an extracorporeal circuit modified from the original of Parks et al.2 In this chapter, we describe the clinical effect of TBHT combined with anticancer chemotherapy and some problems in this area.
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