Abstract
Anemia is characteristic of chronic renal failure with resultant transfusion dependency, especially in growing children maintained on chronic HD. Most of these patients develop Fe overload. Chelation therapy has been used in uremic adults on HD to treat Fe overload, but its use in children has not been detailed. We report a 15-year-old white male who has been on chronic HD for the past 8 years. He has chronic normocytic, normochromic anemia of uremia. To maintain the hematocrit (Hct) above 20% and hemoglobin (Hgb) above 6 gm%, he has received 400 cc of packed red blood cells every 4-5 weeks for the past 6 years. Because of elevated serum ferritin and concern about Fe overload, chelation therapy with D was begun. A dose of 24 mg/kg is infused I.V. during the first hour of HD three times per week. The patient continues with the same transfusion requirements, and no adverse effects of D have been noted. The data indicate that chelation therapy during hemodialysis can be used to treat Fe overload in children to prevent hemosiderosis.CV: corpuscular volume; CHC: corpuscular hemoglobin concentration
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