Abstract
serum at any t ime after ingestion, whereas griseofulvin was present in serum for at least four hours in all children who received the drug with milk; approximately two thirds of nonfasting patients who received 10 and 15 mg /kg doses, respectively, had concentrations greater than 1 #g/ml . A serum concentration of at least 1 ~zg/ml is believed to be necessary for cure of tinea capitis?' It was not possible to determine the half-life of griseofulvin in serum, because peak concentrations occurred at 4 to 6 hours after ingestion and the 24-hour value was thought to reflect, in part, drug that was redistributed from tissues (such as skin 3) to serum in the washout phase. Thus there were too few points from the peak value on the serum concentrat ion-t ime regression curve to calculate accurately the elimination half-life. Because griseofulvin is more consistently detected in serum for up to 24 hours after a 15 mg /kg dose, we recommend this daily dosage regimen for children with superficial fungal infections. The drug should be administered with whole milk or other food containing fat to ensure optimum bioavailability.
Published Version
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