Abstract
Extremely low birth weight (ELBW) infants almost always receive blood transfusions early in life. Newborn infants are currently transfused with leukocyte-depleted, irradiated red blood cells (RBCs) obtained from adult donor, which contains adult hemoglobin. Adult hemoglobin affinity for oxygen is lower than fetal, therefore red cell transfusion could be responsible for increased oxygen delivery to tissues increasing the risk of the “oxygen radicals disease of the newborn”. Though clinical studies have demonstrated that autologous cord blood transfusions in newborns is feasible, the clinical use of umbilical cord blood (UCB) for RBC transfusion purposes is still limited, expecially because of the small volumes achieved after processing of the UCB unit. The preliminary results of the first clinical study assessing the feasibility and the effectiveness of a transfusional program in preterm infants with packed RBSs obtained from allogenic UCB are shown.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.