Use of a severe acute respiratory coronavirus virus 2 (SARS-CoV-2) strand-specific assay to evaluate for prolonged viral replication >20 days from illness onset.

Jessica D Ferguson,Caitlin A Contag,Alex N Zimmet,Melanie Kiener,Guillermo Rodriguez Nava,John Shepard,Ralph Tayyar,Ayelet Rosenthal,Benjamin A Pinsky,Lucy S Tompkins,Jorge L Salinas,Gustavo Contreras,Aruna K Subramanian

doi:10.1017/ice.2023.105

Use of a severe acute respiratory coronavirus virus 2 (SARS-CoV-2) strand-specific assay to evaluate for prolonged viral replication >20 days from illness onset.

Jessica D Ferguson, Caitlin A Contag + Show 11 more

https://doi.org/10.1017/ice.2023.105

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Journal: Infection control and hospital epidemiology

Publication Date: Jun 29, 2023

Affiliation: Stanford Health Care, Stanford University

#Severe Acute Respiratory Coronavirus Virus 2 #Real-time Reverse-transcription Polymerase Chain Reaction #Illness Onset #Acute Respiratory Virus #Strand-specific Assay #Acute Virus #Respiratory Virus #Viral Replication #Prolonged Replication #Real-time Polymerase Chain Reaction

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Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) real-time reverse-transcription polymerase chain reaction (rRT-PCR) strand-specific assay can be used to identify active SARS-CoV-2 viral replication. We describe the characteristics of 337 hospitalized patients with at least 1 minus-strand SARS-CoV-2 assay performed >20 days after illness onset. This test is a novel tool to identify high-risk hospitalized patients with prolonged SARS-CoV-2 replication.

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Use of a severe acute respiratory coronavirus virus 2 (SARS-CoV-2) strand-specific assay to evaluate for prolonged viral replication >20 days from illness onset.