Abstract
We have shown in the rat and in man that it is possible to determine the life span of autologous platelets and to quantify the production of these circulating cells by injecting[ 75Se]-methionine and analysing the overall platelet radioactivity curves obtained: platelets and their precursors are labelled in vivo by adsorption of circulating plasma proteins onto their membrane, and in the marrow, principally during synthesis of thrombosthenin. This last phenomenon takes place 2 to 3 days before platelet release into the rat blood circulation and 5 to 6 days in the case of man. When there is a greatly increased production, the maturation time is slightly decreased.
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