Urine Nerve Growth Factor May Not Be Useful as a Biomarker of Overactive Bladder in Patients with Pelvic Organ Prolapse.

Katarzyna Jankiewicz,Pawel Miotla,Tomasz Rechberger,Michał Bogusiewicz,Artur Rogowski,Łukasz Nowakowski

doi:10.3390/jcm11040971

Abstract

(1) Background: Overactive bladder (OAB) symptoms are frequently present in women with pelvic organ prolapse (POP). Although urinary nerve growth factor (NGF) is a promising biomarker of OAB, little is known about its role in patients with OAB secondary to POP. The aim of the study was to evaluate urinary NGF levels in patients with POP involving the anterior vaginal wall and check if it may serve as a predicting factor for postoperative resolution of OAB symptoms. (2) Methods: Eighty-three Caucasian women included in the study were divided into three groups: pure OAB, one associated with POP (POP&OAB) and a control group composed of healthy volunteers. The urine NGF and creatinine were assessed with ELISA tests to calculate the NGF/creatinine ratio. (3) Results: The NGF/creatinine ratio was significantly higher in patients with pure OAB in comparison with other groups; however, it did not differ between the control group and the POP&OAB group. There was no correlation between NGF/creatinine ratio and age, menopausal status, BMI, parity or urodynamic findings. The NGF/creatinine ratio was not a prognostic factor for OAB symptoms’ resolution after surgical treatment of POP. (4) Conclusions: Urinary NGF excretion is not increased in women with OAB secondary to POP; thus, it may not serve as an OAB biomarker in these patients.

Highlights

Overactive bladder (OAB) is a condition characterized by symptoms of urgency and frequency with or without urge incontinence in the absence of other proven pathologies.Diagnosis is based on medical history and the analysis of the micturition diary [1]
Urodynamic diagnosis of OAB is based on the finding of bladder contraction (DO); incidence of detrusor overactivity (DO) among OAB patients varies in the range of Regarding low sensitivity of Urodynamic study (UDS), other objective tools, such as assessment of biomarkers, have been considered
We aimed to check if the urinary nerve growth factor (NGF)/creatinine ratio may be used as a potential biomarker in women with OAB symptoms secondary to POP

Summary

Introduction

Overactive bladder (OAB) is a condition characterized by symptoms of urgency and frequency with or without urge incontinence in the absence of other proven pathologies.Diagnosis is based on medical history and the analysis of the micturition diary [1]. Urodynamic study (UDS), not required in the diagnostic flow of an OAB patient, may provide more objective data by detecting detrusor overactivity (DO) as well as assessing maximum flow rate (Qmax), maximum cystometric capacity (MCC), voided volume, and detrusor pressure at maximal flow rate (PdetQmax). It excludes overflow incontinence and other pathologies that mimic OAB and confirms urodynamic stress urinary incontinence (SUI) [2]. Based on the finding that urinary NGF concentration may be affected by urine-specific gravity, it has been proposed that measurement of the NGF/creatinine ratio is the most accurate method [5].

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