Urine Culture in Hospitalized Patients during 2014-2018: An Analysis on Pathogen Distribution and Drug Sensitivity.

Dongkai Sun,Lijiang Sun,Peishan Cong,Shuai Liu,Guiming Zhang,Fengju Guan,Yuzhen Xu

doi:10.1155/2021/6646024

Abstract

Objective We sought to analyze the distribution and antibiotic sensitivity of pathogens in hospitalized patients and to provide a scientific reference for the rational application of antibiotics. Methods From January 2014 to December 2018, urine cultures from patients in our hospital were collected and analyzed retrospectively for the presence, distribution, and drug sensitivity of pathogens. Results A total of 42,854 midstream urine cultures were collected from which 11,891 (27.75%) pathogens were isolated, including 8101 (68.13%) strains of gram-negative bacteria, 2580 (21.69%) strains of gram-positive bacteria, and 1210 (10.18%) strains of fungi. Escherichia coli and Enterococci were the most common species of gram-negative and gram-positive bacteria, respectively. Drug sensitivity varied among different pathogens. Clear drug resistance was observed in bacteria, while fungus exhibited relatively lower resistance. Conclusion Pathogens responsible for urinary tract infections in hospitalized patients are diversiform and display resistance to some antibiotics. Drug resistance monitoring should be enhanced to optimize antimicrobial therapy.

Highlights

Urinary tract infections (UTIs) are well established as common clinical infections, caused mainly by gram-negative bacteria
In a study by Arana and colleagues on the prevalence and evolution of multidrug resistance (MDR) profiles, the proportion of hospitalized patients with UTIs caused by Escherichia coli (E. coli) resistant to amoxicillin and ciprofloxacin increased from 5.89% in 2007–2010 to 8.18% in 2011–2014 [5]
We aimed to explore the distribution and drug resistance of pathogenic bacteria in urine cultures of inpatients in a regional central hospital during the past 5 years

Summary

Introduction

Urinary tract infections (UTIs) are well established as common clinical infections, caused mainly by gram-negative bacteria. In recent years, with the development of new broad-spectrum antibiotics and their clinical application, drug resistance in pathogens causing UTIs has become increasingly serious. In a study by Arana and colleagues on the prevalence and evolution of multidrug resistance (MDR) profiles, the proportion of hospitalized patients with UTIs caused by Escherichia coli (E. coli) resistant to amoxicillin and ciprofloxacin increased from 5.89% in 2007–2010 to 8.18% in 2011–2014 [5]. Klebsiella pneumoniae drug resistance is becoming increasingly common. Guidelines by the European Association of Urology (2019 edition) suggest that short-range fluoroquinolones may be used as first-line treatment for patients with uncomplicated pyelonephritis. A European survey on mortality caused by drug-resistant bacterial infections reported that carbapenem-resistant K. pneumoniae and E. coli were the main pathogens causing

Results

Discussion

Conclusion