Abstract
ObjectiveWe want to determine whether urinary myeloperoxidase to creatinine ratio could be served as a new marker for monitoring treatment effects of urinary tract infection or not. MethodsA total of 328 patients suspected of UTI were enrolled in present study. Patients been received antibiotic therapy within two weeks were excluded (n = 26). Patients with urine contaminated specimens (n = 49) and negative urine culture results (n = 96) were also excluded, the remaining culture positive subjects (n = 157) were followed up for 7 to 14 days, finally, a total of 49 subjects were followed up and further divided into cure (n = 35) and none-cure (n = 14) subgroups according to urine culture results. MPO concentration was determined by immunoturbidimetric method and creatinine level was measured by creatinine enzyme method. Two sided P values < 0.05 were considered statistically significant. ResultsUrinary MCR level between before and after antibiotic treatment of cure group were (1437.1 ± 1777.9 vs.48.3 ± 59.3, t = 4.608, P = 0.001), respectively. Urinary MCR level between before and after antibiotic treatment of none-cure group were (1633.1 ± 2168.7 vs. 999.4 ± 1708.0, t = 1.809, P = 0.094), respectively. ConclusionsUrinary MCR could be served as a promising marker for monitoring treatment effects of urinary tract infection.
Published Version
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