Urinary ketone bodies and stroke recurrence in patient with acute ischemic stroke or TIA

Abstract

BackgroundUrine ketone bodies may appear in different states in the acute stage of stroke. We aimed to examine the association between urine ketone bodies and recurrent stroke in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA) in this study. MethodsIn Third China National Stroke Registry (CNSR-III), 14,015 patients with AIS or TIA were screened for urine ketone bodies. The outcomes were any stroke, ischemic stroke and combined vascular events within 1 year. The association of urine ketone bodies with recurrent stroke were analyzed by Cox proportional hazards. ResultsDuring 1 year of follow-up, 1,335 (9.53%) participants experienced recurrent stroke. After adjustment for conventional confounding factors, patients with urine ketone bodies test positive had a higher risk of recurrent stroke (hazard ratio [HR], 1.43; 95% confidence interval [CI], 1.13–1.82), compared to those were negative. The correlation between positive urine ketone bodies and recurrent stroke were consistent in patient with (HR, 1.45; 95% CI, 1.00–2.12) and without (HR, 1.40; 95% CI, 1.02–1.94) diabetes. No significant interaction between urine ketone bodies and diabetes were observed. ConclusionsPositive ketone bodies in urine was independently associated with recurrent stroke in patients with AIS or TIA.