Abstract
A comparative study of the urinary glycoprotein from 30 normal and 60 schizophrenic male subjects of the same age group revealed three remarkable features: (1) a significant decreased excretion of glycoprotein in 24-hr urine of schizophrenic patients, (2) the presence of a significant amount of protein-bound rhamnose in schizophrenic urine in the form of a small molecular weight glycoprotein, and (3) a significantly higher glucosamine/galactosamine ratio in patient's urine glycoprotein along with other differences in molar ratios of other classes of carbohydrate components. Since the amounts and types of glycoproteins and glycosaminoglycans of urine, in general, reflect the metabolism of these macromolecules in connective tissue, the synchronicity in decreased excretion and of higher glucosamine/galactosamine ratios in both glycoproteins observed in this study and also in glycosaminoglycans, reported in our previous study (27) in urine of schizophrenic patients, probably results from an altered metabolism involving a stress on metabolism of glucosamine-containing macromolecules in the connective tissue of the schizophrenic patients.
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