Abstract
DURING recent years several authors have shown that certain hereditary dysostoses are caused by an abnormal deposition in bone and various parenchymatous organs of acid mucopolysaccharides (AMP). Maroteaux and Lamy1 subdivided these mucopolysaccharidoses into five different types according to their characteristic excretion patterns of AMP. In this communication we present our results of a comparable investigation of urinary excretion of individual AMP in normal persons and patients with different types of mucopolysaccharidoses. Through the introduction of column chromatography the determination of AMP pattern in the urine has become an especially valuable tool in the biochemical identification and classification of atypical cases of hereditary dysplasias of bone.
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