Abstract
The authors present the results of using the sequential thin layer chromatographic technique to study normal and pathological urines. A complete separation of urinary acidic glycosamino-glycans was obtained with this method, with greater R F - values than had been reported prior to this study. The convenience of this method for the diagnosis of different types of mucopolysaccharidosis should be stressed. Classification of the different types of mucopolysaccharidosis (MPS) is based both on clinical and genetic criteria and qualitative assay of acidic glycosaminglycans (AGAG) in urine 1,2. Recently, Lippiello and Mankin 3 published a new method for the separation of AGAG, which was applied to tissue but not to urinary AGAG. This paper describes the application of the slightly modified sequential thin layer chromatographic technique to the urine of mucopolysaccharidosis.
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