Abstract
Urinary estrogen excretion in women was assayed using Brown-Kanbegawa's method. The following results were obtained. In the normal menstrual cycle, the peak in urinary estrogen was observed at the ovulation time and the middle luteal phase. Gradual increase after 12 year old in puberty, and gradual decrease after menopause in urinary estrogen were demonstrated, respectively.Urinary estrogen excretion was low in 2° amenorrhea showing abnormally high or low FSH excretion. Urinary estrogen levels remained in normal range in 1° amenorrhea showing normal FSH level and abnormally high or low ranqc of LH excretion. Remarkable daily change in urinary estrogen were demonstrated in dysfunctional uterine bleeding. Anencephalic pregnancy showed low estrogen excretion, estrone as 1/5 low, estradiol as 1/3 low, estriol as 1/15 low as ones in normal pregnancy. Oral contraceptive progestogen induced a peak in urinary estrogen within 3 day after beginning of administration. HPG, HMG and clomiphene citrate induced remarkable increase in urinary estrogen excretion, when they were effective. Urinary estrogen excretion showed tendency of decrease with dexamethasone, no change with ACTH, and increase with thyroid hormone administration.A new formula est imating urinary estrogen level by measuring the amount of cervical mucus was devised.
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