Abstract
In this study, microcapsules with variable mechanical strength were fabricated by layer-by-layer (LBL) assembly based on MnCO3 templates, and the influence of microcapsule stiffness on cellular uptake and cell functions were investigated. The microcapsules were well dispersed in water and had a spherical form of a uniform size. The average layer thickness was calculated to be 18.4 ± 0.4 nm, while the elasticity modulus of the 2- and 10-layer microcapsules was measured to be 1243.3 ± 212.0 and 3309.5 ± 505.7 MPa, respectively. The influence of the microcapsules uptake on cell viability and functions was then studied in terms of cell viability and cytoskeleton organization. The uptake of the microcapsules did not cause an apparent decrease in cell viability or alteration of cell morphology but did change the cytoskeleton organization to some extent.
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